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KMID : 0043320150380111963
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Archives of Pharmacal Research
2015 Volume.38 No. 11 p.1963 ~ p.1969
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Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro
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Kim Ha-Yeong
Kim Hye-Mi
Ryu Byeol
Lee Jae-Seung
Choi Jung-Hye
Jang Dae-Sik
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Abstract
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A new terthiophene, 3′-hydroxy-2,2′:5′,2″-terthiophene-3′-O-β-d-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-d-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2?6), seven triterpenoids (8?14), two coumestans (15 and 16), and four flavonoids (17?20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1?20 were evaluated for their cytotoxicity against human ovarian cancer cells (SKOV3) using MTT assays.
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KEYWORD
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Eclipta prostrata, Terthiophene, Triterpenoid, Cytotoxicity, Ovarian cancer
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